Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring

Ghodrati, Fariba; Mahmoodi, Minoo; Shahidi, Siamak; Ghadimipoure, Hamid Reza

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Volume 3, Issue 1 (Februrary 2016) Avicenna J Neuro Psycho Physiology 2016, 3(1): 6-11 | Back to browse issues page

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Ghodrati F, Mahmoodi M, Shahidi S, Ghadimipoure H R. Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring. Avicenna J Neuro Psycho Physiology 2016; 3 (1) :6-11
URL: http://ajnpp.umsha.ac.ir/article-1-66-en.html

Morphological Effects of Hydroalcoholic Zingiber Officinalis Extract in the Murine Hippocampus of Male Rat Offspring

Fariba Ghodrati¹

, Minoo Mahmoodi

², Siamak Shahidi³

, Hamid Reza Ghadimipoure⁴

1- Department of Biology, Hamadan Branch, Islamic Azad University, Hamadan, IR Iran
2- Department of Biology, Hamadan Branch, Islamic Azad University, Hamadan, IR Iran , minoomahmoodi@yahoo.com
3- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
4- Pathology Ward, Shahid Beheshti Hospital, Hamadan University of Medical Sciences, Hamadan, IR Iran

Abstract: (1612 Views)

Materials and Methods: In this study, 60 rats, 15 males and 45 females, were used. We separated pregnant female rats from males on the first day of pregnancy (determined by vaginal plug), and during days 16 - 18 of pregnancy, via intraperitoneal injection, three groups received hydroalcoholic extract of ginger, with low (200 mg/kg bw), medium (400 mg/kg bw), and high (800 mg/kg bw) concentration doses. The control group did not receive anything, and the sham group received normal saline during these days. Then at day 50, the males offspring in each group were sacrificed, their brains were removed, and the hippocampus sections were prepared for microscopic studies. Data was analyzed by SPSS 20 and by using one-way ANOVA and then a Tukey post-test (P < 0.05 considered as the significance level).

Keywords: Ginger, Memory, Offspring, Male Rats, Hippocampus

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Article Type: Research Article | Subject: Special
Received: 2016/01/2 | Accepted: 2016/02/15 | Published: 2016/02/28

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