Volume 12, Issue 1 (March 2025)
Avicenna J Neuro Psycho Physiology 2025, 12(1): 1-9 |
Back to browse issues page
Ethics code: IR.UI.REC.1399.097
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Arab-Moghaddam N, Asgari Mobarakeh K. Mental Health and Cognitive Function across Multiple Sclerosis Subtypes. Avicenna J Neuro Psycho Physiology 2025; 12 (1) :1-9
URL: http://ajnpp.umsha.ac.ir/article-1-508-en.html
URL: http://ajnpp.umsha.ac.ir/article-1-508-en.html
1- Assistant Professor of ACECR , narabmoghaddam@yahoo.com
2- Associate Professor
2- Associate Professor
Abstract: (683 Views)
Background and Objective: Mental health problems (e.g., depression, stress, and anxiety) are debilitating symptoms in individuals with multiple sclerosis (MS), and may be associated with cognitive dysfunction across different subtypes of the disease. This study aimed to compare cognitive performance across MS subtypes and examine the relationships between mental health symptoms and cognitive functions, in order to explore potential patterns of cognitive vulnerability in patients at various stages of MS, compared to healthy controls.
Materials and Methods: A total of 97 participants aged 18-49 years old were included in this study. They consisted of 25, 24, and 24 patients with Newly-Diagnosed MS (ND), Relapsing-Remitting MS (RRMS), and Secondary Progressive MS (SPMS), respectively, as well as 24 healthy controls (HC). All participants completed standardized assessments of cognitive function and mental health status.
Results: Comparisons among the patient groups revealed differences in cognitive functions and mental health problems, particularly depression and stress. The HC and ND groups had higher scores in most cognitive tests, especially when compared to the SPMS group. However, the ND group showed higher levels of depression and stress, compared to others. Significant negative correlations were observed between ND and RRMS groups in terms of mental health problems and certain cognitive functions.
Conclusion: These findings suggest that mental health difficulties may be linked to cognitive performance even in the early stages of MS. The results underscore the importance of early psychological screening and supportive interventions to help mitigate cognitive challenges throughout the course of the disease.
Materials and Methods: A total of 97 participants aged 18-49 years old were included in this study. They consisted of 25, 24, and 24 patients with Newly-Diagnosed MS (ND), Relapsing-Remitting MS (RRMS), and Secondary Progressive MS (SPMS), respectively, as well as 24 healthy controls (HC). All participants completed standardized assessments of cognitive function and mental health status.
Results: Comparisons among the patient groups revealed differences in cognitive functions and mental health problems, particularly depression and stress. The HC and ND groups had higher scores in most cognitive tests, especially when compared to the SPMS group. However, the ND group showed higher levels of depression and stress, compared to others. Significant negative correlations were observed between ND and RRMS groups in terms of mental health problems and certain cognitive functions.
Conclusion: These findings suggest that mental health difficulties may be linked to cognitive performance even in the early stages of MS. The results underscore the importance of early psychological screening and supportive interventions to help mitigate cognitive challenges throughout the course of the disease.
Article Type: Research Article |
Subject:
Cognition
Received: 2024/12/12 | Accepted: 2025/06/9 | Published: 2025/07/19
Received: 2024/12/12 | Accepted: 2025/06/9 | Published: 2025/07/19
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Articles Copyright © The Author(s).
Owned by Hamadan University of Medical Sciences.
Published by UMSHA Press
Journal Tel: +989025126654
Publisher Tel: +985136014377
Website: http://ajnpp.umsha.ac.ir
Email: avicennajnpp[at]gmail.com
