Volume 11, Issue 3 (September 2024)
Avicenna J Neuro Psycho Physiology 2024, 11(3): 125-131 |
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Ionov I, Krasilova M, Pushinskaya I, Gorev N, Tulchinskiy V, Gabov S. Synergy of somatostatin – substance P receptors antagonists in the initiation of catalepsy in rats. Avicenna J Neuro Psycho Physiology 2024; 11 (3) :125-131
URL: http://ajnpp.umsha.ac.ir/article-1-486-en.html
URL: http://ajnpp.umsha.ac.ir/article-1-486-en.html
Ilya Ionov1 
, Maria Krasilova2 , Irina Pushinskaya3 , Niсholas Gorev3 , Victor Tulchinskiy3 , Sergey Gabov4
, Maria Krasilova2 , Irina Pushinskaya3 , Niсholas Gorev3 , Victor Tulchinskiy3 , Sergey Gabov4
1- 1 Head, Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia , newrology@yandex.ru
2- Senior Researcher, Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia
3- Researcher, Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia
4- Senior Technical Expert, Timpharm LTD, Moscow, 117513, Russia
2- Senior Researcher, Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia
3- Researcher, Department of Neurometabolic Analysis, Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, 109029, Russia
4- Senior Technical Expert, Timpharm LTD, Moscow, 117513, Russia
Abstract: (335 Views)
The parkinsonian brain undergoes a decrease in levels of somatostatin (SST) and substance P (SP). According to previous studies, brain SST deficit in rats simulated by i.c.v. injections of SST receptor antagonist, cyclosomatostatin (cSST), increases the speed of catalepsy development. Nevertheless, it is not clear how the SP, a natural ligand of neurokinin-1 (NK1) receptors, contributes to the growth of catalepsy.
The present study aimed to find out whether simultaneous blockade of central somatostatin and NK1 receptors can lead to catalepsy, a model for parkinsonian bradykinesia and rigidity. The experiments were conducted on Wistar rats. The blockade of somatostatin and NK1 receptors was simulated by intracerebroventricular injections of cSST and substance L-733,060, respectively. Bar test was used to evaluate the catalepsy. No catalepsy was induced by cSST at 1.0 µg and L-733,060 at 10.0 ng injected separately. Nevertheless, co-administration of these agents led to a clear cataleptic response. Cataleptogenic action of the combination was reversed by SP. Based on such results, cSST and L-733,060 can synergistically induce catalepsy in the rat. According to these findings, Parkinson’s disease-associated brain deficit in SST and SP could be relevant for pathogenesis of extrapyramidal dysfunctions. Considering the aforementioned findings, the processes mediated by central SST and NK1 receptors could be possible therapeutic targets for parkinsonism.
The present study aimed to find out whether simultaneous blockade of central somatostatin and NK1 receptors can lead to catalepsy, a model for parkinsonian bradykinesia and rigidity. The experiments were conducted on Wistar rats. The blockade of somatostatin and NK1 receptors was simulated by intracerebroventricular injections of cSST and substance L-733,060, respectively. Bar test was used to evaluate the catalepsy. No catalepsy was induced by cSST at 1.0 µg and L-733,060 at 10.0 ng injected separately. Nevertheless, co-administration of these agents led to a clear cataleptic response. Cataleptogenic action of the combination was reversed by SP. Based on such results, cSST and L-733,060 can synergistically induce catalepsy in the rat. According to these findings, Parkinson’s disease-associated brain deficit in SST and SP could be relevant for pathogenesis of extrapyramidal dysfunctions. Considering the aforementioned findings, the processes mediated by central SST and NK1 receptors could be possible therapeutic targets for parkinsonism.
Article Type: Research Article |
Subject:
Movement disorders
Received: 2024/05/17 | Accepted: 2024/09/20 | Published: 2025/02/24
Received: 2024/05/17 | Accepted: 2024/09/20 | Published: 2025/02/24
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