Nikkhah A,  Ghahremanitamadon F,  Zargooshnia S,  Shahidi S,  Soleimani Asl S. Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study.  Avicenna J Neuro Psycho Physiology 2014; 1 (1) :1-4
URL: 
http://ajnpp.umsha.ac.ir/article-1-23-en.html    
                    
                    
                    
					 
					
                 
                
                    
                    
                    
                    1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran  
                    
                    
                    Abstract:        (3177 Views) 
                    
                    
                    
Background:  Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD.
 
Objective:  Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment.
 
Materials and Methods:  Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task.
 
Results:  The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task.
 
Conclusions:  These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats.
 
                     
                    
                    
                    
                    
                    Article Type:  
Research Article  |
                    Subject: 
                    
Special   Received: 2014/03/1 | Accepted: 2014/04/19 | Published: 2014/08/25