Nikkhah A, Ghahremanitamadon F, Zargooshnia S, Shahidi S, Soleimani Asl S. Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study. Avicenna J Neuro Psycho Physiology 2014; 1 (1) :1-4
URL:
http://ajnpp.umsha.ac.ir/article-1-23-en.html
1- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran 2- Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran; Department of Anatomy, Hamadan University of Medical Sciences, Hamadan, IR Iran
Abstract: (2677 Views)
Background: Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD.
Objective: Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment.
Materials and Methods: Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task.
Results: The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task.
Conclusions: These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats.
Article Type:
Research Article |
Subject:
Special Received: 2014/03/1 | Accepted: 2014/04/19 | Published: 2014/08/25