Sargholi Nootarki Z, Kesmati M, Poormehdi Borujeni M. Effect of Magnesium Oxide Nanoparticles on Atropine-Induced Memory Impairment in Adult Male Mice. Avicenna J Neuro Psycho Physiology 2015; 2 (4) :106-112
URL:
http://ajnpp.umsha.ac.ir/article-1-64-en.html
1- Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, IR Iran 2- Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, IR Iran , m.kesmati@scu.ac.ir 3- Department of Food Hygiene, Shahid Chamran University, Ahvaz, IR Iran
Abstract: (2386 Views)
Background: Previous studies have shown that magnesium oxide nanoparticles (MgO-n) improve passive avoidance memory in adult male mice. Alternatively, muscarinic receptors of the cholinergic system have a primary role in memory formation but their relationship with the improvement effects of magnesium on memory is not clear.
Objectives: The aim of this study was to investigate the effect of nano magnesium oxide on memory deficits induced by atropine as a muscarinic receptor antagonist in passive avoidance memory tests.
Materials and Methods: In this experimental study, NMRI male mice were placed in groups receiving atropine (0.1 and 1 mg/kg), recipient of MgO-n (1, 2.5, and 5 mg/kg) and groups receiving atropine in effective dose and different doses of MgO-n were used. Saline was used as a vehicle for drugs in the control groups. Memory was evaluated with a step-down apparatus to determine the coming down latency from a safe platform on days 1, 3, and 7 after training. Locomotor activity was also evaluated through an open field test in all groups after memory measurements.
Results: The results showed that atropine (1 mg/kg) decreased the latency time of coming down from the podium and induced memory deficits (P < 0.01). MgO-n in doses of 2.5 and 5 mg/kg caused a significant increase in latency time of coming down from the podium over one week (P < 0.001). MgO-n was able to reverse memory impairments resulting from atropine (1 mg/kg) (P < 0.001). Locomotor activity did not change in any of the groups.
Article Type:
Research Article |
Subject:
Special Received: 2015/10/1 | Accepted: 2015/11/15 | Published: 2015/11/28