Volume 13, Issue 2 (June 2026)
Avicenna J Neuro Psycho Physiology 2026, 13(2): 0-0 |
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Ethics code: IR.SHAHED.REC.1399.106
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Lakzaei F, Karami M. Short-term treatment with low concentrations of L-arginine reduces allostatic load in aged Wistar rats. Avicenna J Neuro Psycho Physiology 2026; 13 (2)
URL: http://ajnpp.umsha.ac.ir/article-1-568-en.html
URL: http://ajnpp.umsha.ac.ir/article-1-568-en.html
1- Department of Biology, Faculty of Basic Sciences, Shahed University
2- Department of Biology, Faculty of Basic Sciences, Shahed University ,karami@shahed.ac.ir
2- Department of Biology, Faculty of Basic Sciences, Shahed University ,
Abstract: (3 Views)
Introduction: The allostatic load score is assessed based on functional and structural dysregulation of the brain and endocrine system, including markers of pro-inflammatory factors, such as nitric oxide (NO). This score increases with age, and one of the criteria for measuring this score is the examination of the status of endocrine glands, including the pituitary and ovaries. To investigate allostatic load, we studied the feedback efficacy of L-arginine supplementation, a precursor of NO, at a dose of 5 mg/kg for short- to long-term periods on the ratio of steroid hormone (estrogen)/gonadotropin (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) levels in aged female Wistar rats.
Materials & Methods: Animals (weighing 250 to 300 g) were divided into control and experimental groups and received saline (1 mL/kg) and L-arginine (5 mg/kg) intraperitoneally once a day for 3 to 21 days, respectively. After treatment, blood samples were taken from the hearts of rats under deep anesthesia, and ovarian feedback on gonadotropins was analyzed. In addition, the gonads were examined histopathologically. The body weight index of all animals was compared between the pre- and post-treatment periods. The data were analyzed using analysis of variance (ANOVA) with an error coefficient (α=0.05).
Results: Treatment with L-arginine over 3 days significantly (P< 0.05) improved ovarian feedback function, as measured by the steroid/gonadotropin level ratio. However, the ovaries became swollen during the long-term treatment period, indicating an inflammatory response, and body mass index decreased.
Conclusion: Low-dose L-arginine over a few days may correct allostatic overload by improving ovarian function and improving steroid feedback on pituitary gonadotropins.
Materials & Methods: Animals (weighing 250 to 300 g) were divided into control and experimental groups and received saline (1 mL/kg) and L-arginine (5 mg/kg) intraperitoneally once a day for 3 to 21 days, respectively. After treatment, blood samples were taken from the hearts of rats under deep anesthesia, and ovarian feedback on gonadotropins was analyzed. In addition, the gonads were examined histopathologically. The body weight index of all animals was compared between the pre- and post-treatment periods. The data were analyzed using analysis of variance (ANOVA) with an error coefficient (α=0.05).
Results: Treatment with L-arginine over 3 days significantly (P< 0.05) improved ovarian feedback function, as measured by the steroid/gonadotropin level ratio. However, the ovaries became swollen during the long-term treatment period, indicating an inflammatory response, and body mass index decreased.
Conclusion: Low-dose L-arginine over a few days may correct allostatic overload by improving ovarian function and improving steroid feedback on pituitary gonadotropins.
Article Type: Research Article |
Subject:
Physiology
Received: 2026/01/24 | Accepted: 2026/04/29 | Published: 2026/06/20
Received: 2026/01/24 | Accepted: 2026/04/29 | Published: 2026/06/20
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