Volume 9, Issue 4 (November 2022)                   Avicenna J Neuro Psycho Physiology 2022, 9(4): 144-149 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Banihashemi S, Khorshidian N, Iranpour Broujeni B, Haghighinejad H. Impact of Depressed Mood as a Risk Factor on COVID-19 Disease Severity. Avicenna J Neuro Psycho Physiology 2022; 9 (4) :144-149
URL: http://ajnpp.umsha.ac.ir/article-1-436-en.html
1- Armaghan Health Care Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Enghelab Health Care Center, Shiraz University of Medical Sciences, Shiraz, Iran
3- Health Sciences Center, Oklahoma State University, Tulsa, United States of America
4- Department of Family Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , hhaghighi@sums.ac.ir
Abstract:   (636 Views)
Background and Objective: The results of many studies have shown that depression can cause weakened cellular immune control, decreased antibody response to some vaccines, and the development and exacerbation of numerous medical disorders, including viral disease. This study aimed to investigate the relationship between the severity of COVID-19 disease and depression.
Materials and Methods: In this cross-sectional multicenter study, conducted between February 2021 and March 2021, patients were randomly selected at the time of positive results of reverse transcription polymerase chain reaction for COVID-19, and called to assess for a history of depression within the previous two weeks using the Patient Health Questionnaire (PHQ-9). Afterward, 14 days later, they were asked about the COVID-19 infection course.
Results: The number of days a patient had a fever, decreased sense of smell or taste, and other symptoms were higher in depressed than in non-depressed individuals (P<0.05). Patients with COVID-19 symptoms (fever and decreased smell or taste) and consequences (hospitalized and intubated) had higher PHQ-9 scores than patients without these symptoms (P<0.05). Moreover, 46.2% of depressed and 18.5% of non-depressed patients reported complications of the disease (including renal, gastrointestinal, vascular, neurological, and skin complications), which was statistically significant (p-value exact test:0.026).
Conclusions: There was a significant relationship between depression and the duration and severity of COVID-19. This preliminary study suggested that baseline depression had adverse effects on the seriousness of COVID-19 disease. More studies with substantial evidence are needed to confirm the causality effect
Full-Text [PDF 1420 kb]   (120 Downloads) |   |   Full-Text (HTML)  (105 Views)  
Article Type: Research Article | Subject: Depression
Received: 2022/10/26 | Accepted: 2023/03/14 | Published: 2023/03/19

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY 4.0 | Avicenna Journal of Neuro Psycho Physiology

Designed & Developed by : Yektaweb