en Health Education and Promotion پژوهشي Research Article <span style="font-size:12px;"><span style="font-family:Tahoma;"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="color:black">Background and Objective:</span></b> The present study aimed to examine the effect of Acceptance and Commitment Therapy (ACT) on pain perception and self-care in individuals with migraines.<b><span dir="RTL" lang="FA"><span style="font-family:&quot;Times New Roman&quot;,serif"></span></span></b></span></span><br> <span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="color:black">Materials and Methods:</span></b> A quasi-experimental pretest&ndash;posttest design with a control group was conducted at Shahid Fahmideh Hospital, Tehran, Iran, from 2023 to 2024. The sample consisted of 24 (12 per group) women with migraine headaches who were purposively selected and assigned to the intervention and control groups. The experimental group received eight 90-min ACT sessions; the control group received no intervention. Pain perception and self-care were measured using the Short-Form McGill Pain Questionnaire and the Madah Questionnaire. Moreover, data were analyzed by multivariate analysis of covariance (MANCOVA).<span dir="RTL" lang="FA"><span style="font-family:&quot;Times New Roman&quot;,serif"></span></span></span></span><br> <span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="color:black"><span style="letter-spacing:.1pt">Results:</span></span></b> The findings indicated that the effect of group assignment on overall pain perception and its components&mdash;including sensory, affective, evaluative, and self-care dimensions was significant. After controlling for pretest scores, a significant difference between the groups was found (P<0.01)</span></span><br> <span style="line-height:normal"><span style="unicode-bidi:embed"><b>Conclusions: </b>The findings indicate that ACT reduces pain perception and improves self-care behaviors in women with migraines, suggesting it may be an effective psychological intervention for this population.</span></span></span></span><br> &nbsp; Acceptance and Commitment Therapy (ACT), Migraine, Pain perception, Self-care 56 61 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2651-1&slc_lang=en&sid=1 Najme Fathalizade se.fathalizade@iau.ac.ir 10031947532846009182 0009-0009-9548-918X No Department of Psychology, Ro.C., Islamic Azad University, Roudehen, Iran Fariba Bashardoost Tajali faribabashardoost@iau.ac.ir 10031947532846009183 10031947532846009183 Yes Department of Psychology, Ro.C., Islamic Azad University, Roudehen, Iran. Narges Babakhani nargesbabakhani@iau.ac.ir 10031947532846009184 10031947532846009184 No Department of Psychology, Ro.C., Islamic Azad University, Roudehen, Iran.