@ARTICLE{Nikkhah, author = {Nikkhah, Ali and Ghahremanitamadon, Fatemeh and Zargooshnia, Somayeh and Shahidi, Siamak and Soleimani Asl, Sara and }, title = {Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study}, volume = {1}, number = {1}, abstract ={Background: Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objective: Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Materials and Methods: Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task. Results: The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. Conclusions: These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats. }, URL = {http://ajnpp.umsha.ac.ir/article-1-23-en.html}, eprint = {http://ajnpp.umsha.ac.ir/article-1-23-en.pdf}, journal = {Avicenna Journal of Neuropsychophysiology}, doi = {10.17795/ajnpp-18664}, year = {2014} }