Volume 8, Issue 1 (February 2021)                   Avicenna J Neuro Psycho Physiology 2021, 8(1): 1-6 | Back to browse issues page

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Gohari Nasab A, Seyrafi M, Kraskian A, Kalhornia Golkar M. Effectiveness of Acceptance and Commitment Therapy in Health Anxiety and Adherence to Treatment in Patients Undergoing Open-Heart Surgery. Avicenna J Neuro Psycho Physiology. 2021; 8 (1) :1-6
URL: http://ajnpp.umsha.ac.ir/article-1-272-en.html
1- Department of Psychology, Kish International Branch, Islamic Azad University, Kish Island, Iran.
2- Assistant Professor, Department of Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran. , mohamadreza.seirafi@kiau.ac.ir
3- Assistant Professor, Department of Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran.
4- Assistant Professor, Department of Psychology, Karaj Branch, Islamic Azad University, Karaj, Iran
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Cardiovascular disease (CVD) is the most common cause of mortality among non-communicable diseases. In 2012, about 17.5 million patients died of CVD, accounting for 31% of all mortalities worldwide. According to the results of 10 centers for chronic disease prevention, CVD is one of the three most common diseases causing mortality in individuals over the age of 35 [1]. According to the World Health Organization, by 2020, CVD will be the leading cause of mortality worldwide. In terms of infection, mortality, disability, and economic cost, it will be the most important disease and cause of mortality by 2020. In Iran, about 90,000 mortalities annually occur due to this disease [2].
The findings suggest that CVD is associated with diseases and other problems, which can lead to many problems in occupational performance, sleep function, cancer, obesity, and lifestyle. Stress experiences cause physiological changes in the heart and arteries, which in turn increases CVD [3]. However, negative psychological factors, such as depression, anxiety, and hostility, play an important role in the development and progression of
heart disease [4]. Instead, findings show that psychological well-being plays an important and useful role in reducing the risk of heart disease [5].
Recent studies have emphasized the importance of the influence of psychological and emotional factors as the most important risk factors in CVD. In addition, periods of acute stress or intense excitement can lead to cardiovascular attacks [6]. Among various factors playing a role in the development and severity of heart disease, the role of psychological factors of stress and lifestyle is very important [7]. These factors have caused the severity of the disease to increase and create major psychological problems for these individuals, regarded as a series of chains increasing and intensifying cardiovascular problems in these patients. Among the psychological factors that these patients are struggling with, anxiety is associated with illness and distress [8].
Psychological distress is associated with changes
in the nervous-glandular system, hypothalamic-pituitary and adrenal axis, platelet function, and heart rate [9]. The evidence has shown that individuals with lower levels of stress exhibit avoidant behaviors or do not express their emotions in stressful situations [10]. These factors increase the risk of health anxiety in cardiac patients [11]. Anxiety is a disorder in which individuals suffer from severe anxiety and worry about their body and health without realizing that they are at risk or suffering from a specific illness and consider simple physical symptoms to be serious illnesses. If this anxiety is exacerbated, individuals may feel self-conscious so that this anxiety is an alternative to the patientʼs self-disorder [12]. The results show that 51% of chronic patients suffer from this anxiety [13]. This anxiety leads to maladaptive avoidance of conditions, such as visiting family members or exercising [14].
There have been a limited number of studies carried out on health anxiety in cardiac patients; nevertheless, numerous studies have been conducted on patients with stress and anxiety [15, 16]. In a study, Hayes examined the differences among health anxiety, depression, and anxiety in individuals with heart and non-cardiac problems and concluded that the levels of anxiety, depression, and health anxiety were higher in individuals with coronary artery disease [17]. Acceptance and commitment therapy (ACT) is an intervention enhancing the level of well-being, reducing the level of distress, and increasing psychological resilience [18]. Numerous treatments and commitment-based interventions, including large-scale randomized trials, to improve the health and quality of life of cardiac patients, have not yet been performed [19].
In a research sample with a small group without a control group, Goodwin et al. demonstrated that a program based on ACT promoted patientsʼ cardiac health behaviors. The program also increased following diet and doing physical activity [20]. The ACT improved the psychological well-being of cardiac patients and reduced the risk factors for heart disease. Therefore, ACT is suggested for the reduction of mortality and increase in the quality of life among these patients [21]. Acceptance and commitment-based therapy has also been studied regarding anxiety disorders. Hoffmann et al. showed that the treatment based on group acceptance and commitment is logical, effective, and acceptable in the treatment of severe health anxiety [22]. In a study carried out by Hood et al., it was indicated that ACT reduced the level of health anxiety during the three-month follow-up with a large intragroup effect size of 0.66 [23].
As previously mentioned, heart disease is one of the biggest problems in the health care system. These patients have incurred staggering costs on the family and health care system due to health anxiety and lack of follow-up treatment. Health psychology has tried to play a significant role in the prevention and treatment of this disease using psychological concepts. The use of new cognitive therapies in the field of health has recently received much attention.
Given that CVD is on the rise in the community and coronary artery bypass grafting is being used as a common treatment for these patients, depression is also common in these patients. Therefore, it is necessary to pay special attention to the psychological issues related to these patients. As a result, due to the wide range of physical and psychological problems of cardiac patients and need to pay attention to their health issues, this study aimed to evaluate the effectiveness of ACT in health anxiety and adherence to treatment of individuals undergoing open-heart surgery.
Materials and Methods
The research method was semi-experimental with a pre-test and post-test design. The statistical population of this study included all the patients undergoing open-heart surgery and referring to Valiasr Hospital in Ghaemshahr, Mazandaran, Iran, in 2019. By interviewing and examining the inclusion and exclusion criteria, the subjects were selected using the targeted sampling method and randomly divided them into two groups. The criterion for selecting the number of the sample based on a previous study [24] was an effect size of 0.25, alpha of 0.05, and power of 0.80 in the two groups. The minimum number of the sample to achieve the desired power was 15 subjects in each group; therefore, a total of 30 individuals were selected for the present study.
The inclusion criteria were not receiving psychotropic drugs, narcotics, and psychological therapies during the study, being over 40 years of age, and not suffering from acute or chronic mental disorders. The exclusion criteria were no attendance at trial and intervention sessions for more than two sessions, unwillingness to continue attending trial and intervention sessions, severe psychiatric disorders requiring immediate treatment, and use of psychedelics or drugs. In this study, in coordination with Social Security Treatment Management of Mazandaran province and director of Valiasr Hospital in Ghaemshahr, it was requested to introduce patients undergoing open-heart surgery to the researcher. Subsequently, the researcher
Table 1. Content of acceptance and commitment therapy sessions
Session Content
Session 1 Taking the test, familiarizing the patient with octave therapy, and examining the heart disease in each individual (the duration of the disease and taken measures)
Session 2 Explaining the relationship among pain, mood, and judgment and calling for creative helplessness
Session 3 Finding patient controlling methods through constructive frustration, introducing desire and acceptance as a technique, and examining the expense of unwillingness and non-acceptance
Session 4 Reviewing previous assignments, finding faults, and developing acceptance and desire techniques
Session 5 Reviewing previous assignments, weakening dependence on conceptualized self, developing awareness of self-observation, and distinguishing between self-conceptualization and self-observation
Session 6 Self-textual training, reviewing being in the present, alternative attachment to the past, and future-conceptualization, and training mindfulness techniques
Session 7 Clarifying values, being in the present, and reviewing previous assignments
Session 8 Assessing the assignments of previous session, teaching committed behaviors, removing obstacles, carrying out a final evaluation, and performing post-test
randomly selected two experimental and control groups and then trained one of the groups in eight sessions of ACT. However, the control group did not receive any intervention. Finally, considering the position for teaching the independent variables, the necessary data for the analysis were collected by performing pre-test and then post-test. Eventually, 15 individuals were prepared for each group to perform the analysis.
The ethical considerations were observed in the present study. All the individuals received oral information about the study and participated in the study if they were willing to. The participants were assured that all the information would remain confidential and will be used for research objectives. In order to respect privacy, the names and surnames of the participants were not registered.
Health Anxiety Questionnaire
This questionnaire was developed by Salkousis and Varis in 2002 for the measurement of health anxiety [24]. The questionnaire has 18 items measuring health anxiety based on a 5-point Likert scale. This questionnaire has three sections discussing the general health concerns of the negative consequences and main part. The validity of this questionnaire was obtained by Shahidi et al. at 0.90, and Cronbachʼs alpha coefficient for this questionnaire was obtained within the range of 0.70-0.82 [25].
Adherence to Treatment Questionnaire
Seyed Fatemi et al. developed this questionnaire in order to observe adherence to treatment in chronic patients in 2017 [26] with 48 items. Careful treatment, willingness to participate in treatment,
ability to adapt, integration with life therapy, adherence to treatment, and hesitation in the implementation of treatment characterize 40 items based on a 5-point Likert scale from fully agree to fully disagree. The reliability of this scale was confirmed using internal consistency with a Cronbachʼs alpha coefficient of 0.92 [27].
The ACT was performed in eight 90-minute sessions once a week for 2 months based on the Hayes training package. The validity of this package has been confirmed by its developers and it has high formality and content validity [28]. In addition, the content validity of this educational package was approved by five professors of psychology at University of Tehran, Tehran, Iran, and then it was used in the present study. Table 1 tabulates a summary of the contents of ACT sessions.
In addition to using average descriptive statistics and standard deviation, the data were analyzed based on multivariate analysis of covariance (MANCOVA) using SPSS software (version 22). The MANCOVA assumptions were assessed using the Leveneʼs test, variance homogeneity test, and regression slope homogeneity test. Furthermore, the normality of data distribution was examined using the Shapiro-Wilk test. A follow-up test was also utilized to compare the groups. The significance level of the tests in this study was considered to be 0.05.
The obtained results showed that the mean values of cardiac patientsʼ age in the experimental and control groups were 51.47±4.37 and 52.8±14.14 years, respectively (Table 2). In addition, the results
Table 2. Mean and standard deviation of study variables in experimental and control groups
Research variable Group Pre-test Post-test
Mean Standard deviation Mean Standard deviation
Health anxiety ACT 58.57 6.09 25.67 3.09
Control 55.60 8.77 55.33 8.60
Adherence to treatment ACT 120.88 6.14 173 6.45
Control 124.80 7.22 126.81 6.56
ACT: Acceptance and commitment therapy
Table 3. Results of multivariate analysis of covariance for comparison of ­ mean health anxiety and adherence to treatment
Dependent variable Sum of square df Mean of square F P Eta
Health anxiety 8100.92 2 4050.460 83.609 0.0001 0.80
Adherence to treatment 21574.816 2 10787.408 271.328 0.0001 0.92

of the Chi-square test demonstrated that there was no significant difference between the two groups in terms of age. Table 3 shows the mean values of the experimental and control groups regarding the variables under study.
Before performing the covariance analysis test, the Shapiro-Wilk and Levene’s tests were used to assess the required assumptions. The Shapiro-Wilk test for the distribution of research variables in the pre-test and post-test stages showed that the study variables had a normal distribution. The Levene’s test was employed to predict the homogeneity of the error variances. The results of the Levene’s test indicated that the homogeneity assumption of variances was accepted. The examination of the homogeneity of regression slopes also demonstrated that the assumption of homogeneity of regression slopes was also established. Therefore, there were prerequisites for MANCOVA. Table 3 tabulates the results of covariance analysis.
The results of Table 3 revealed that the mean scores of health anxiety and follow-up in the experimental and control groups were significantly different from each other due to the larger F-value calculated than the critical F-value at the level of 0.05 (3.23). To be more precise, between the experimental groups and control group in terms of health anxiety (F=61.83; P=0.0001; Eta=0.80) and adherence to treatment (F=271.33; P=0.0001; Eta=0.92), there was a significant difference in the elimination of the effect of pre-test averages. It can also be concluded that based on the coefficients of segregation the therapeutic intervention had a very strong effect on the explanation of the dependent variable. More precisely, ACT (group-independent variables) accounted for 80.3% in explaining health anxiety and 92.8% in explaining adherence to treatment in patients undergoing open-heart surgery.
The present study aimed to determine the effectiveness of ACT in health anxiety and adherence to treatment in patients undergoing open-heart surgery. The obtained findings showed that acceptance-based therapy reduced the health anxiety of the experimental group, compared to that reported for the control group. The results of the current study are consistent with the findings of studies conducted by Hoffman et al. and Elinberg et al. [10, 22]. The results also showed that this therapy increased the follow-up of the treatment of
these patients.
To explain the above-mentioned results, it should be said that acceptance-based therapy is on the basis of the principle taught to cardiac patients that deal with this disorder instead of avoiding anxiety-provoking situations, especially health anxiety, by increasing psychological acceptance of internal experiences, such as thoughts and feelings, that they have when thinking about their heart disease, and by setting goals for their illness and commitment to them [11].
Capacity is one of the main factors that has improved patientsʼ mental health. The ACT taught cardiac patients how to release their inhibitory thoughts keeping them stressed and anxious, escape from disturbing thoughts, accept their internal events that they control pathologically, and analyze them instead of avoiding them [13]. One of the biggest problems that individuals with cardiac problems face is the engagement with verbal tags as heart disease. This has caused both the patient and those around him/her to use this label for the individual. The ACT allows individuals with heart disease to get rid of the verbal control causing their problems to spread and allow them to stop arguing with them [14]. This treatment does not seek to make patients with heart disease think more realistically but rather to avoid negative psychological experiences, thereby increasing their awareness and focusing on the moment to improve their health. All of these factors can also increase the chances of following the treatment in these patients.
As previously mentioned, one of the basic principles of treatment is based on acceptance and commitment to the reduction of the empirical avoidance of patients with heart disease [17]. Other individuals do not run away from their feelings and emotions and try to accept them as they are. During the therapy sessions, the therapist tried to convince patients not to run away from their illness, especially the label. These factors generally work together to ensure that an individual not only does not reduce adherence to his or her follow-up diet and medication but also promotes it [15]. Therefore, these individuals are less afraid of verbal labels, such as heart disease, and try to accept and make them a part of their lives. That is why they accept to increase their commitment to the use of drugs day by day. As the treatment of these individuals continues, they learn to refrain from pain and confusion in order to reduce these experiences. Then, their function is enhanced by increasing their level of psychological resilience [12].
It can be concluded that ACT was effective in the adherence to treatment and reduction of health anxiety. The obtained results of the present study suggested that ACT significantly increases adherence to treatment and decreases the health anxiety of cardiac patients.
Compliance with ethical guidelines
All the ethical principles were observed in the present study. The participants were informed about the purpose of the study and implementation of the stages. In addition, informed consent was obtained from all the study subjects. The patients were also assured of the confidentiality of their information. Moreover, the subjects were free to withdraw from the study at any time, and the results would be available to the participants if desired.
The authors would like to express their gratitude to the participants who greatly cooperated in conducting the present study.
Authorsʼ contributions
Conceptualization [Arezou Gohari Nasab]; Methodology [Mohammadreza Seyrafi]; Investigation [Adis Kraskian]; Writing Original Draft [Maryam Kalhornia Golkar]; Writing, Reviewing, and Editing [All authors]; Funding Acquisition [All authors]; Resources [All authors]; Supervision [Mohammadreza Seyrafi]
The current study did not receive any specific grant from funding agencies in public, commercial, or not-for-profit sectors.
Conflicts of Interest
The authors declare that there is no conflict of interest.
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Article Type: Research Article | Subject: Health Education and Promotion
Received: 2020/06/4 | Accepted: 2020/07/12 | Published: 2021/02/2

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