en تخصصي Special پژوهشي Research Article <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span>&nbsp;Magnetoencephalography (MEG) is a well-established noninvasive method for investigating human brain activity.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objectives:</span>&nbsp;The present study aimed at identifying any change in the brain state after pico- Tesla Transcranial Magnetic Stimulation (pT-TMS) on patients with multiple sclerosis (MS).</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Methods:</span>&nbsp;A whole-head 122 - channel MEG system in a magnetically shielded room with low magnetic noise was used. The study population comprised of 2 male and 8 female volunteers with MS, with a mean age of 41.3 &plusmn; 9.5 years. External magnetic field of pT-TMS was applied on the above patients with proper field characteristics (magnetic field amplitude: 1 - 7.5 pT, frequency: the alpha rhythm of the patient 8 - 13 Hz), obtained prior to the application of pT-TMS.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span>&nbsp;A significant effect was observed with an increase of frequencies in the range of 2 - 7 Hz among the participants. The results were statistically significant in 7 out of 10 patients (70%).</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Conclusions:</span>&nbsp;The pT-TMS has the prospective to be a significant noninvasive secure and effective means in managing MS symptoms.</p> </aside> MEG, Multiple Slerosis, pT-TMS, Brain Frequencies 73 79 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-55&slc_lang=en&sid=1 Photios Anninos pans.photios.anninos@gmail.com 1003194753284600260 1003194753284600260 Yes Laboratory of Medical Physics, Department of Medicine, School of Health Sciences and Department of Electrical Engineering, Polytechnic School, Democritus University of Thrace Alexandroupoli 68100, Greece Adam Adamopoulos 1003194753284600261 1003194753284600261 No Laboratory of Medical Physics, Department of Medicine, School of Health Sciences and Department of Electrical Engineering, Polytechnic School, Democritus University of Thrace Alexandroupoli 68100, Greece Athanasia Kotini 1003194753284600262 1003194753284600262 No Laboratory of Medical Physics, Department of Medicine, School of Health Sciences and Department of Electrical Engineering, Polytechnic School, Democritus University of Thrace Alexandroupoli 68100, Greece Nicolaos Tsagas 1003194753284600263 1003194753284600263 No Laboratory of Medical Physics, Department of Medicine, School of Health Sciences and Department of Electrical Engineering, Polytechnic School, Democritus University of Thrace Alexandroupoli 68100, Greece