en تخصصي Special پژوهشي Research Article <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span>&nbsp;The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objectives:</span>&nbsp;Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Methods:</span>&nbsp;Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span>&nbsp;Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Conclusions:</span>&nbsp;These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis.</p> </aside> Ecstasy, NeuN, Hippocampus, Rat 44 47 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-50&slc_lang=en&sid=1 Fahimeh Ghasemi Moravej 1003194753284600236 1003194753284600236 No Cell Therapy Division of Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran ; Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran Iraj Amiri 1003194753284600237 1003194753284600237 No Cell Therapy Division of Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran ; Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran Siamak Shahidi 1003194753284600238 1003194753284600238 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Mehdi Mehdizadeh 1003194753284600239 1003194753284600239 No Faculty of Advanced Technologies in Medicine, Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, IR Iran Asrin Rahimi 1003194753284600240 1003194753284600240 No Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran Banafsheh Esmaeilzadeh 1003194753284600241 1003194753284600241 No Faculty of Medicine, Anatomy Department, Bushehr University of Medical Sciences, Bushehr, IR Iran Sara Soleimani Asl s.soleimaniasl@umsha.ac.ir 1003194753284600242 1003194753284600242 Yes Cell Therapy Division of Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran ; Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran