en تخصصي Special پژوهشي Research Article <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span>&nbsp;Previous studies have shown that magnesium oxide nanoparticles (MgO-n) improve passive avoidance memory in adult male mice. Alternatively, muscarinic receptors of the cholinergic system have a primary role in memory formation but their relationship with the improvement effects of magnesium on memory is not clear.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objectives:</span>&nbsp;The aim of this study was to investigate the effect of nano magnesium oxide on memory deficits induced by atropine as a muscarinic receptor antagonist in passive avoidance memory tests.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Materials and Methods:</span>&nbsp;In this experimental study, NMRI male mice were placed in groups receiving atropine (0.1 and 1 mg/kg), recipient of MgO-n (1, 2.5, and 5 mg/kg) and groups receiving atropine in effective dose and different doses of MgO-n were used. Saline was used as a vehicle for drugs in the control groups. Memory was evaluated with a step-down apparatus to determine the coming down latency from a safe platform on days 1, 3, and 7 after training. Locomotor activity was also evaluated through an open field test in all groups after memory measurements.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span>&nbsp;The results showed that atropine (1 mg/kg) decreased the latency time of coming down from the podium and induced memory deficits (P < 0.01). MgO-n in doses of 2.5 and 5 mg/kg caused a significant increase in latency time of coming down from the podium over one week (P < 0.001). MgO-n was able to reverse memory impairments resulting from atropine (1 mg/kg) (P < 0.001). Locomotor activity did not change in any of the groups.</p> </aside> Atropine, Magnesium, Memory, Nanoparticles 106 112 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-42&slc_lang=en&sid=1 Zeinab Sargholi Nootarki 1003194753284600202 1003194753284600202 No Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, IR Iran Mahnaz Kesmati m.kesmati@scu.ac.ir 1003194753284600203 1003194753284600203 Yes Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, IR Iran Mahdi Poormehdi Borujeni 1003194753284600204 1003194753284600204 No Department of Food Hygiene, Shahid Chamran University, Ahvaz, IR Iran