en تخصصي Special پژوهشي Research Article <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span>&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">Urtica dioica</i>&nbsp;(nettle) has a variety of uses in traditional medicine for the treatment of certain urogenital problems, gastrointestinal disorders, and diabetes.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objectives:</span>&nbsp;Recent studies have implicated the effect of&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;on brain functions such as pain and memory. However, there is no direct evidence of the acute effects of this plant on cognition. The aim of the present study was to evaluate the effect of&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;aqueous extract on the novel object-recognition task (NOR) in mice.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Materials and Methods:</span>&nbsp;First,&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;aqueous extract was prepared, then adult male mice were randomly divided into four experimental groups. During the training session, the mice were placed in a box and given 5 minutes to explore two identical objects. The next day, they were again placed in the box and allowed to explore one familiar and one novel object. They received intraperitoneal injections of saline or&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;aqueous extract (100 mg/kg) before or immediately after the training session or before the test session of the NOR task.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span>&nbsp;The results showed that there was a preference for the novel object compared to the familiar one in each of the experimental groups. The object-recognition discrimination index in the group of mice that received&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;before training was significantly less than in the other experimental groups. There was no significant difference in the discrimination index between the other groups.&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;did not decrease the time spent exploring familiar and unfamiliar objects, or the total time spent exploring both objects.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Conclusions:</span>&nbsp;Acute administration of&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;impairs the object-recognition task if it is used only before the training session. This may be due to its modulation on the acquisition processing of object-recognition.&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>&nbsp;has no significant effects on the consolidation or retrieval processing stages of the NOR task. These results emphasize the unfavorable effect on cognitive function of pre-training with acute supplementation of&nbsp;<i style="box-sizing: border-box; word-wrap: break-word;">U. dioica</i>.</p> </aside> Mice, Novel Object Recognition, Urtica dioica 79 82 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-37&slc_lang=en&sid=1 Nasrin Hashemi-Firouzi 1003194753284600157 1003194753284600157 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Marjan Akhavan 1003194753284600158 1003194753284600158 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Alireza Komaki 1003194753284600159 1003194753284600159 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Siamak Shahidi siamakshahidi@yahoo.com 1003194753284600160 1003194753284600160 Yes Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran