Avicenna Journal of Neuropsychophysiology

en Impact of Acceptance and Commitment Therapy-based Training Program on the Quality of Life, Anxiety, and Depression in Women with Systemic Lupus Erythematosus in Tehran Health Education and Promotion پژوهشي Research Article Background and Objective: Systemic lupus erythematosus (SLE), as a chronic and debilitating disease, causes anxiety in affected people and leads to worry and tension in response to threatening conditions, and ultimately, results in decreased quality of life. Therefore, it is highly critical to apply appropriate training interventions to mitigate the potential psychological consequences in such patients. One of the training methods is Acceptance and Commitment Therapy (ACT), which has been addressed in a few studies. Therefore, the present study aimed to assess the effect of the ACT program on the quality of life, anxiety, and depression in women suffering from SLE  in Tehran. Materials and Methods: This quasi-intervention study was performed on 30 SLE-afflicted women residing in Tehran in 2024. The participants were selected via the convenience sampling method and randomly allocated to two intervention and control groups (n=15 in each group). The data were collected by the World Health Organization Quality of Life Questionnaires (WHOQOL-BREF) and the Hospital Anxiety and Depression Scale (HADS), which were completed by the control and intervention groups before and two months after the intervention. The data were analyzed in SPSS Software (version 27) using the Wilcoxon test, Mann-Whitney U test, and Fisher's exact test. Results: The results of the Mann-Whitney test indicated that before the training intervention, no statistically significant difference was observed between the intervention and control groups in terms of the mean score of quality of life (P=0.945), depression (P=0.612), and anxiety (P=0.095), while after the training intervention, a significant difference was spotted between the two groups in quality of life, depression, and anxiety (P<0.05). Conclusion: The results of the present study demonstrated the positive effect of the ACT program on women suffering from SLE. The findings of this study can be employed first for the patients themselves, then for their families, the countrywide medical universities, and the Ministry of Health. Furthermore, they can provide valuable information for designing and planning future interventions.   Anxiety, Depression, Quality of life, Systemic lupus erythematosus, Women 33 40 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-1379-1&slc_lang=en&sid=1 Minoo Irani Mehr.ir10090@yahoo.com 10031947532846008514 0009-0007-6891-4457 No Department of Psychology, Payam-e-Noor University, Tehran, Iran. Hossein Zare hzare882@gmail.com 10031947532846008515 10031947532846008515 Yes Department of Psychology, Payam-e-Noor University, Tehran, Iran. ‌Mohammad Oraki M.oraki@pnu.ac.ir 10031947532846008516 10031947532846008516 No Department of Psychology, Payam-e-Noor University, Tehran, Iran. Ezatallah Kordmirza Nikoozadeh kordmirza@pnu.ac.ir 10031947532846008517 10031947532846008517 No Department of Psychology, Payam-e-Noor University, Tehran, Iran. ‌Amin Rafieipour rafiepoor@pnu.ac.ir 10031947532846008518 10031947532846008518 No Department of Psychology, Payam-e-Noor University, Tehran, Iran.