en تخصصي Special پژوهشي Research Article <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span>&nbsp;Lead (Pb<span style="box-sizing: border-box; word-wrap: break-word; position: relative; font-size: 9px; line-height: 0; vertical-align: baseline; top: -0.5em;">2+</span>) is a neurotoxin substance that has been known for its adverse effects on central nervous system and memory. Previous studies reported the potential effect of vitamin E as a memory enhancer.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objectives:</span>&nbsp;The purpose of the present study was to assess the protective effects of vitamin E against Pb-induced amnesia.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Materials and Methods:</span>&nbsp;Forty-eight male Wistar rats (200-250 g) were divided equally into the saline, Pb, Pb + vitamin E, and vitamin E alone groups. To induce Pb toxicity, rats received water that contained 0.2% Pb instead of regular water for 1 month. Rats pretreated, treated or post treated with vitamin E (150 mg/kg) for 2 months. Passive avoidance learning was assessed using Shuttle-Box after two months. Retention was tested 24 and 48 hours after training.</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span>&nbsp;The results showed that Pb caused impairment in acquisition and retrieval processes in passive avoidance learning. Vitamin E reversed learning and memory deficits in pre, post or co- exposure with Pb (P < 0.001).</p> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Conclusions:</span>&nbsp;According to the results of this study, administration of vitamin E to rats counteracts the negative effects of Pb on learning and memory. To more precisely extrapolate these findings to humans, future clinical studies are warranted.</p> </aside> Lead, Vitamin E, Avoidance Learning 30 33 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-23&slc_lang=en&sid=1 Iraj Salehi 100319475328460095 100319475328460095 Yes Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Maryam Sahab Soleimani 100319475328460096 100319475328460096 No Department of Physiology, School of Sciences, Hamadan Branch, Islamic Azad University, Hamadan, IR Iran Mahsa Poorhamze 100319475328460097 100319475328460097 No Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran Fahimeh Ghasemi Moravej 100319475328460098 100319475328460098 No Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran Alireza Komaki 100319475328460099 100319475328460099 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Sara Soleimani Asl s.soleimaniasl@umsha.ac.ir 1003194753284600100 1003194753284600100 No Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran