en عمومى General پژوهشي Research Article <p><b>Background and Objective:&nbsp;</b>Resilience refers to a protective factor that reduces stress in people with multiple sclerosis (PwMS). Given the significance of this issue, the present research aimed to assess the validity and reliability of the Connor-Davidson Resilience Scale (CD-RISC) in PwMS.<br> <b>Materials and Methods:</b>&nbsp;The present cross-sectional study aimed to assess the psychometric properties of CD-RISC in the statistical population of Guilan MS Society (GMSS). In this study, 442 people with MS participated and responded to CD-RISC in an online survey. The data were analyzed in SPSS (version 23) and Amos (version 21) software packages.<br> <b>Results:</b>&nbsp;The confirmatory factor analysis results of the first stage with five factors revealed that 25 CD-RISC items benefited from high factor load and good fit indices were reported (ꭕ2=605.55; df=265; P-Value=.0001; ꭕ2/df=2.28; GFI=.88; CFI=.93; TLI=.92; RMR=.06; RMSEA=.05); therefore, CD-RISC has good construct validity. Cronbach&rsquo;s alpha coefficients for the whole scale and subscales were calculated at 0.94 and 0.71-0.89, respectively, indicating the optimal reliability of CD-RISC in PwMS.<br> <b>Conclusions:&nbsp;</b>The current study presented evidence for CD-RISC validity and reliability. Further studies are recommended to ensure the psychometric properties of this scale in other chronic patients.</p> Multiple Sclerosis (MS), Psychometric, Reliability, Resilience, Validity 45 50 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-540-1&slc_lang=en&sid=1 Babak Bakhshayesh Eghbali babak.bakh@gmail.com 10031947532846005708 10031947532846005708 No Associate Professor of Neurology, Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Ali Pourramzani dr_pourramzani@yahoo.com 10031947532846005709 10031947532846005709 No Assistant Professor, Department of Psychiatry, Kavosh Behavioural, Cognitive and Addiction Sciences Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Amir Hossein Bahadivand Chegini amiralibahadivand@gmail.com 10031947532846005710 10031947532846005710 No MA of General Psychology, Prisoners Organization and Security and Educational Measures, Education and Research Center, Gilan, Iran. Laila Mirniam leilamirniam@yahoo.com 10031947532846005711 10031947532846005711 No MA in Counseling, Department of Counseling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran. Keivan Hasanzadeh keivan.mars@gmail.com 10031947532846005712 10031947532846005712 No Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Sajjad Saadat sajjadsaadat69@gmail.com 10031947532846005713 10031947532846005713 Yes PhD in Psychology, Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.