Avicenna Journal of Neuropsychophysiology
1
Avicenna J Neuro Psycho Physiology
Medical Sciences
http://ajnpp.umsha.ac.ir
1
admin
2383-2436
2383-2444
8
7
14
8888
13
en
jalali
1393
8
1
gregorian
2014
11
1
1
2
online
1
fulltext
en
Effect of Lemon Verbena on Memory of Male Rats
تخصصي
Special
پژوهشي
Research Article
<aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;">
<p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span> Lemon verbena (<i style="box-sizing: border-box; word-wrap: break-word;">Lippia citriodora</i>) has been known to have various pharmacologic activities.</p>
</aside>
<aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;">
<p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objectives:</span> Lemon verbena leaves are used to make an herbal tea, which is traditionally used for treating spasms, common cold, severe abdominal pain, indigestion, insomnia, anxiety, and headache. Although it has been known to have various pharmacologic activities, no scientific study has been done to assess its effects yet. In this study aimed to assess the effect of the aqueous extract of lemon verbena on memory of male rats by using the passive avoidance task.</p>
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<p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Materials and Methods:</span> In this study, Wistar male rats (weight, 180-250 g) were recruited. Aqueous extract of lemon verbena leaves was prepared. A total of 40 Wistar male rats were randomly allocated to five groups (n = 8). Saline for control group and aqueous extract of lemon verbena in four experimental groups were administered intraperitoneally (respectively 10, 100, 500, and 1000 mg/kg) for seven days. Then passive avoidance learning test was used to evaluate learning and memory. On the seventh day, acquisition test was performed an hour after treatment and the retention test was performed on the next day.</p>
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<aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;">
<p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span> Analysis of data showed that in comparison to controls, treatment with the aqueous extract of lemon verbena (≥ 100 mg/kg) had decreased the step-through latency (STL) (P < 0.001). Moreover, treatment of the rats with the extract doses of ≥ 500 mg/kg had increased the total time spent in the dark compartment (TDC) in comparison to controls (P < 0.001).</p>
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<aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;">
<p style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Conclusions:</span> These results indicated that aqueous extract of lemon verbena (≥ 100 mg/kg) has undesirable effects on memory; however, understanding the underling mechanisms needs further investigation.</p>
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Vervain, Learning, Memory, Rats
69
72
http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-16&slc_lang=en&sid=1
Mojgan
Veisi
100319475328460064
100319475328460064
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
Siamak
Shahidi
siamakshahidi@yahoo.com
100319475328460065
100319475328460065
Yes
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
Alireza
Komaki
100319475328460066
100319475328460066
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran
Abdolrahman
Sarihi
100319475328460067
100319475328460067
No
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran