en Depression پژوهشي Research Article <span style="font-family:Tahoma;"><span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:8.0pt"><span style="color:black">Background and Objective: </span></span></b><span style="font-size:8.0pt">Kaempferol (KM) is a flavonoid found in plant-derived foods and medicinal plants. Recently, it has been well established that KM plays a protective role against the development of Alzheimer&#39;s disease. This study evaluated the effect of intracerebroventricular microinjection of KM on depression and identified the potentially related serotonergic mechanisms in rats. </span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:8.0pt"><span style="color:black">Materials and Methods:</span></span></b> <span style="font-size:8.0pt">Male rats were assigned to control, vehicle (dimethyl sulfoxide), KM, fluoxetine, cyproheptadine, KM (20 </span><span style="font-size:8.0pt">m</span><span style="font-size:8.0pt">g/rat) + cyproheptadine (1 </span><span style="font-size:8.0pt">m</span><span style="font-size:8.0pt">g/rat), and KM (20 </span><span style="font-size:8.0pt">m</span><span style="font-size:8.0pt">g/rat) + cyproheptadine (4 </span><span style="font-size:8.0pt">mg/rat) groups. All the groups received their respective treatments for 30 days. Depression was evaluated by both forced swimming and tail suspension tests. Monoamine oxidase-A (MAO-A), as a neurochemical parameter, was also evaluated in the liver and brain of animals.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:8.0pt"><span style="color:black"><span style="letter-spacing:.1pt">Results:</span></span></span></b> <span style="font-size:8.0pt">Treatment with KM significantly decreased immobility time in both forced swimming and tail suspension tests, compared to the vehicle. In the forced swimming test, remarkable effects in immobility time were induced by KM + cyproheptadine after a single dose during weeks 2, 3, and 4 of treatment, compared to the cyproheptadine group. In the tail suspension test, both fluoxetine and KM indicated remarkable effects in the immobility time during weeks 3 and 4. In addition, in both the brain and liver, MAO-A activity was decreased after treatment with KM.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:8.0pt"><span style="color:black">Conclusions: </span></span></b><span style="font-size:8.0pt">These results indicated the antidepressant-like effects of KM through the involvement of 5HT2 receptors in male rats.</span></span></span></span></span> Depression, Flavonoids, Intraventricular, Monoamine oxidase 23 30 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-422-2&slc_lang=en&sid=1 Mohammad Zarei mmmzarei@yahoo.com 10031947532846005499 10031947532846005499 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Saeed Mohammadi smiauhphd.sm@gmail.com 10031947532846005500 10031947532846005500 Yes Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Alireza Komaki Alirezakomaki1@gmail.com 10031947532846005501 10031947532846005501 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Zoleikha Golipour Choshali professor12214@gmail.com 10031947532846005502 10031947532846005502 No Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran