en تخصصي Special پژوهشي Research Article <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <div style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="font-size:12px;"><span style="font-family:tahoma;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Background:</span> Alzheimer&#39;s disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid &beta;-peptide (A&beta;) has a pivotal role in the pathogenesis of AD.</span></span></div> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <div style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="font-size:12px;"><span style="font-family:tahoma;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Objective:</span> Given the contradictory results of A&beta; (25-35) on the memory, in the present study we have examined the effect of A&beta; - induced memory impairment.</span></span></div> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <div style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="font-size:12px;"><span style="font-family:tahoma;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Materials and Methods:</span> Wistar male rats received an intrahippocampal (IHP) injection of A&beta; (25-35).The learning function in the rats was examined by the passive avoidance task.</span></span></div> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <div style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="font-size:12px;"><span style="font-family:tahoma;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Results:</span> The results showed that A&beta; (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task.</span></span></div> </aside> <aside style="box-sizing: border-box; font-family: Lato, Arial; word-wrap: break-word; margin-bottom: 10px; font-size: 11px;"> <div style="box-sizing: border-box; word-wrap: break-word; margin: 0px 0px 10px; font-size: 12px; text-align: justify;"><span style="font-size:12px;"><span style="font-family:tahoma;"><span style="box-sizing: border-box; word-wrap: break-word; font-weight: 700;">Conclusions:</span> These data suggest that single bilateral microinjection of A&beta; (25-35) could impair memory and can be used as an AD model in Wistar rats.</span></span></div> </aside> Alzheimer's disease, Amyloid β-peptide, Learning, Rats 1 4 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-1&slc_lang=en&sid=1 Ali Nikkhah 10031947532846004 10031947532846004 Yes Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Fatemeh Ghahremanitamadon 10031947532846005 10031947532846005 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Somayeh Zargooshnia 10031947532846006 10031947532846006 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Siamak Shahidi 10031947532846007 10031947532846007 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran Sara Soleimani Asl s.soleimaniasl@umsha.ac.ir 10031947532846008 10031947532846008 No Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran; Department of Anatomy, Hamadan University of Medical Sciences, Hamadan, IR Iran