en Substance abuse, dependence, addiction پژوهشي Research Article <div style="text-align: justify;"><strong>Introduction</strong>: Drug addiction treatment may be associated with more challenges and problems in women compared with men.&nbsp;<br> <strong>Objectives</strong>: The present research aimed at determining the impact of group schema therapy on adjusting the early maladaptive schemas in drug-dependent women.<br> <strong>Materials and Methods</strong>: The present research was an experimental study with a pretest-posttest design and a control group. The statistical population included all of the women with substance abuse disorder who referred to the addiction recovery centers in Rasht from November to December 2019. Using a randomized sampling, 60 individuals were selected and assigned into the experimental and control groups (n=30 for each group) and completed the Young Schema Questionnaire - Short Form Version 3 (YSQ-S3). The experimental group was subjected to the schema therapy, whereas the control group did not receive any intervention. The data were analyzed using a one-way Analysis of Covariance (ANCOVA) and Multivariate Analysis of Covariance (MANCOVA) by SPSS V. 22 software.<br> <strong>Results</strong>:&nbsp; The results showed that group schema therapy decreased early maladaptive schemas, including disconnection and rejection (P<0.01), self-control and impaired performance (P<0.01), impaired limits (P<0.003), and over vigilance and inhibition (P<0.001).<br> <strong>Conclusion</strong>: Based on the results, schema therapy reduced the dimensions of early maladaptive schemas, such as disconnection and rejection, self-control and impaired performance, impaired limits, and over vigilance and inhibition in drug-dependent women, however it did not decrease the other-directness dimension.</div> Female, Psychotherapy, Substance-related disorders 123 130 http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-162-3&slc_lang=en&sid=1 Shahram Tirandaz sskrk92@gmail.com 10031947532846002011 10031947532846002011 No Department of Psychology, Rasht Branch, Islamic Azad University, Rasht, Iran. Bahman Akbari Akbari@iaurasht.ac.ir 10031947532846002012 10031947532846002012 Yes Department of Psychology, Rasht Branch, Islamic Azad University, Rasht, Iran.