TY - JOUR JF - umsha-ajnpp JO - Avicenna J Neuro Psycho Physiology VL - 1 IS - 1 PY - 2014 Y1 - 2014/8/01 TI - Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study TT - N2 - Background: Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objective: Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Materials and Methods: Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task. Results: The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. Conclusions: These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats. SP - 1 EP - 4 AU - Nikkhah, Ali AU - Ghahremanitamadon, Fatemeh AU - Zargooshnia, Somayeh AU - Shahidi, Siamak AU - Soleimani Asl, Sara AD - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran KW - Alzheimer's disease KW - Amyloid β-peptide KW - Learning KW - Rats UR - http://ajnpp.umsha.ac.ir/article-1-23-en.html DO - 10.17795/ajnpp-18664 ER -